LITERATURE REVIEW ON MISUSE OF OTC DRUGS IN THE COMMUNITY: PATTERNS, CAUSES, AND SOLUTIONS
Main Article Content
Khairunnisa Azani Meilinasary
Mathla'il Fajri
This study aims to systematically examine the misuse of over-the-counter (OTC) drugs in the community based on national and international research published between 2020 and 2025. A qualitative literature review was conducted by thematically analyzing 15 relevant scientific articles. The findings indicate common misuse patterns, including consumption without medical indication, overdose, long-term use, and neglect of side effects or drug interactions. The contributing factors are multifactorial, such as low medication literacy, misleading advertisements, misconceptions about OTC safety, and inadequate pharmacist supervision. On the other hand, proposed solutions include community-based educational approaches, redesign of pharmacy systems, and the utilization of digital health technologies such as telepharmacy. These findings highlight the urgent need for integration of public education, regulation, and service innovation to reduce the risk of OTC misuse.
Alfian, SD, Sania, JA, Aini, DQ, Khoiry, QA, Griselda, M., Ausi, Y., Zakiyah, N., Puspitasari, IM, Suwantika, AA, Mahfud, M., Aji, S., Abdulah, R., & Kassianos, AP (2024a). Evaluation of usability and user feedback to guide telepharmacy application development in Indonesia: a mixed-methods study. BMC Medical Informatics and Decision Making, 24(1). https://doi.org/10.1186/s12911-024-02494-3
Alfian, SD, Sania, JA, Aini, DQ, Khoiry, QA, Griselda, M., Ausi, Y., Zakiyah, N., Puspitasari, IM, Suwantika, AA, Mahfud, M., Aji, S., Abdulah, R., & Kassianos, AP (2024b). Evaluation of usability and user feedback to guide telepharmacy application development in Indonesia: a mixed-methods study. BMC Medical Informatics and Decision Making, 24(1), 130. https://doi.org/10.1186/s12911-024-02494-3
Algarni, M., Hadi, M.A., Yahyouche, A., Mahmood, S., & Jalal, Z. (2021a). A mixed-methods systematic review of the prevalence, reasons, associated harms and risk-reduction interventions of over-the-counter (OTC) medicines misuse, abuse and dependence in adults. Journal of Pharmaceutical Policy and Practice, 14(1), 76. https://doi.org/10.1186/s40545-021-00350-7
Algarni, M., Hadi, M.A., Yahyouche, A., Mahmood, S., & Jalal, Z. (2021b). A mixed-methods systematic review of the prevalence, reasons, associated harms and risk-reduction interventions of over-the-counter (OTC) medicines misuse, abuse and dependence in adults. Journal of Pharmaceutical Policy and Practice, 14(1), 76. https://doi.org/10.1186/s40545-021-00350-7
Al Mazrouei, N., Ibrahim, RM, Al Meslamani, AZ, Abdel-Qader, DH, & Mohamed Ibrahim, O. (2021). Virtual pharmacist interventions on abuse of over-the-counter medications during COVID-19 versus traditional pharmacist interventions. Journal of the American Pharmacists Association, 61(3), 331–339. https://doi.org/10.1016/j.japh.2021.02.003
Anindyaguna, A., Mustofa, S., Anggraini, DI, & Oktarlina, RZ (2022). Drug-Induced Liver Injury Due to Paracetamol Abuse. In Rasmi Zakiah Oktarlina | Drug-Induced Liver Injury Due to Paracetamol Abuse Medulla | (Vol. 12).
Ayenew, W., Tessema, T.A., Anagaw, Y.K., Siraj, E.A., Zewdie, S., Simegn, W., Limenh, L.W., Tafere, C., & Yayehrad, A.T. (2024). Prevalence and predictors of self-medication with antibiotics in Ethiopia: a systematic review and meta-analysis. In Antimicrobial Resistance and Infection Control (Vol. 13, Issue 1). BioMed Central Ltd. https://doi.org/10.1186/s13756-024-01417-1
Azzahra, F., Astuti, AD, Arifin, B., & Alam, G. (2024). Scoping Review: Study of Herbs Consumption for Self-Medication in Indonesia 2019-2022. Traditional Medicine Magazine, 29(3), 302. https://doi.org/10.22146/mot.94091
Azzahra, N., Sujarwo, P., Dewi, SP, Primanita, SM, Angelia, C., Choiron, DS, Dewi, HK, Penta, Z., Ginting, A., Wisnu, B., Wardhana, K., Rizky, S., Amalia, M., Fesha Ayura, A., & Nugraheni, G. (2023). Level of Public Knowledge and Behavior regarding Online Distribution of Drugs and Food. In Jurnal Farmasi Komunitas (Vol. 10, Issue 2). https://orcid.org/0000-0002-8791-8556
Chladek, JS, Gilson, AM, Stone, JA, Berbakov, ME, Watterson, TL, Lehnbom, EC, Hoffins, EL, Hemesath, KA, Moon, J., Welch, LL, Walbrandt Pigarelli, DL, Portillo, EC, Resendiz, SM, Mai, S., & Chui, MA (2024). The High Prevalence and Complexity of Over-the-Counter Medication Misuse in Older Adults. Innovations in Aging, 8(10). https://doi.org/10.1093/geroni/igae083
Fany Septyasari, A., Putri, A., Nurhaini, R., Anggiara Hastikanuari, A., & Studi, PD (2023). Overview of Knowledge on the Use of Non-Prescription Drugs in Karangduren Village, Kebonarum District, Klaten Regency. In Journal of Pharmaceutical Sciences (Vol. 14, Issue 2).
Fathorrahman, I., Athiyah, U., Rahem, A., Ming, LC, Renganathan, E., Al-Worafi, YM, & Hermansyah, A. (2025). Investigating Community Pharmacist Experiences with Telepharmacy in the Absence of Regulatory Support in Indonesia. Journal of Epidemiology and Global Health, 15(1), 71. https://doi.org/10.1007/s44197-025-00368-z
Ghinan Sholih, M., Ratnasari, D., & R. Utami, M. (2022). MITIGATION OF OVER-THE-COUNTER (OTC) DRUG ABUSE THROUGH EDUCATION IN THE KARAWANG COMMUNITY. Jurnal Mitra Masyarakat, 3(2), 13–17. https://doi.org/10.47522/jmm.v3i2.142
Gilson, AM, Stone, JA, Morris, AO, Brown, RL, Xiong, KZ, Jacobson, N., Holden, RJ, Albert, SM, Phelan, CH, Walbrandt Pigarelli, DL, Breslow, RM, Welch, L., & Chui, MA (2021). Impact of a pilot community pharmacy system redesign on reducing over-the-counter medication misuse in older adults. Journal of the American Pharmacists Association, 61(5), 555–564. https://doi.org/10.1016/j.japh.2021.04.007
Hadi, AEG, & Destiwati, R. (2024). The Influence of Non-Prescription Over-the-Counter Drug Advertisements on Television on Self-Medication Behavior in the Use of Flu Symptom Relief Medication in West Java. Journal of Information and Communication Technology, 8(2), 2024. https://doi.org/10.35870/jti
Ilma, DL, Putri, KM, Mustikaningtias, I., Shobayar, NK, & Parmasari, DH (2024). Telepharmacy knowledge, attitude, and experience among pharmacy students in Indonesia: A cross-sectional study. Pharmacy Education, 24(1), 40–47. https://doi.org/10.46542/pe.2024.241.4047
Indiani, R., Sholih, MG, & Hilmi, IL (2023). Factors Influencing the Use of Over-the-Counter Drugs among UNSIKA Students. Journal of Science and Health, 5(4), 514–520. https://doi.org/10.25026/jsk.v5i4.1364
Janz, N. K., & Becker, M. H. (1984). The Health Belief Model: A Decade Later. Health Education Quarterly, 11(1), 1–47. https://doi.org/10.1177/109019818401100101
Kurniasari, S., Fairuz Zabadi, A., Ramadhani, F., & Nurin Azizah, A. (2021). Level of Knowledge of the Bettet Pamekasan Village Community regarding the Use of Over-the-Counter and Limited Over-the-Counter Drugs for Self-Medication. In JOURNAL OF PHARMACY SCIENCE AND PRACTICE I (Vol. 8).
Ma, C., & Zhang, H. (2025). A cross-sectional study on self-medication with over-the-counter drugs among adolescents: an analysis of current practices. Frontiers in Public Health, 13. https://doi.org/10.3389/fpubh.2025.1560299
Masumoto, S., Yamakawa, T., Sakamoto, N., & Maeno, T. (2023). Association between health literacy and medication comprehension; attitudes toward reporting adverse events in adults using over-the-counter medicines. Journal of Pharmaceutical Policy and Practice, 16(1). https://doi.org/10.1186/s40545-023-00596-3
Medisa, D., Suryanegara, FDA, Natalia, DA, Handayani, PF, Kusuma, DPI, & Nugraheni, DA (2020). Public knowledge of self-medication in Ngaglik subdistrict of Sleman regency. Indonesian Journal of Medicine and Health, 11(3), 250–256. https://doi.org/10.20885/JKKI.Vol11.Iss3.art6
Nasif, H., Andrelva, CB, & Sari, YO (2023). Pharmacy Staff's Recommendations for Self-Medication Requests on Non-Infectious Productive Cough: A Study in Padang City, Indonesia. Journal of Pharmaceutical & Clinical Sciences, 10(3), 264. https://doi.org/10.25077/jsfk.10.3.264-269.2023
Nazaryan, L., Barseghyan, A., Rayisyan, M., Beglaryan, M., & Simonyan, M. (2024). Evaluating consumer self-medication practices, pharmaceutical care services, and pharmacy selection: a quantitative study. BMC Health Services Research, 24(1), 10. https://doi.org/10.1186/s12913-023-10471-1
Pineles, L.L., & Parente, R. (2013). Using the theory of planned behavior to predict self-medication with over-the-counter analgesics. Journal of Health Psychology, 18(12), 1540–1549. https://doi.org/10.1177/1359105312465912
Rosenstock, I. M. (1974). Historical Origins of the Health Belief Model. Health Education Monographs, 2(4), 328–335. https://doi.org/10.1177/109019817400200403
Sinuraya, RK, Wulandari, C., Amalia, R., & Puspitasari, IM (2023). Public Knowledge, Attitudes, and Practices Regarding the Use of Over-The-Counter (OTC) Analgesics in Indonesia: A Cross-Sectional Study. Patient Preference and Adherence, Volume 17, 2569–2578.https://doi.org/10.2147/PPA.S426290
Smith, S. M., Schroeder, K., & Fahey, T. (2014). Over-the-counter (OTC) medications for acute cough in children and adults in community settings. Cochrane Database of Systematic Reviews, 2014(11).https://doi.org/10.1002/14651858.CD001831.pub5
Sudhewa, SPBVD, Widowati, IGAR, Empuadji, PP, Suryaningsih, NPA, & Sutema, IAMP (2023). Self-Medication in the Pandemic Era: Factors to Consider Based on the Theory of Health Belief Model. PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia), 20(1), 59.https://doi.org/10.30595/pharmacy.v0i0.15071